Zostavax (Zoster Vaccine Live), Is It For You?
Zostavax is a live vaccine developed by Merck & Co. which has been shown to reduce the incidence of herpes zoster (known as Shingles) by 51.3% in a pivotal phase III study of 38,000 adults aged 60 and older who received the vaccine. The vaccine also reduced by 66.5% the number of cases of postherpetic neuralgia and reduced the severity and duration of pain and discomfort associated with shingles, by 61.1%.
Zostovax was approved by the FDA in May, 2006. The FDA recommended it only for adults aged 60 who meet the following requirements:
- Has not had a life-threatening allergic reaction to gelatin, the antibiotic neomycin, or other component of the herpes zoster vaccine.
- Does not have a weakened immune system due to HIV/AIDS or another disease or medications (such as steroids, radiation and chemotherapy) that affect the immune system.
- Does not have a history of cancer affecting the bone marrow or lymphatic system, such as leukemia or lymphoma.
- Does not have active, untreated tuberculosis.
On October 25th, 2006, the CDC’s Advisory Committee on Immunization Practices (ACIP) voted to recommend that Zostavax be given to all adults age 60 and over, including those who have had a previous episode of shingles
What is ZOSTAVAX and how does it work?
ZOSTAVAX is a vaccine that is used for adults 60 years of age or older to prevent shingles (also known as zoster). ZOSTAVAX contains a weakened chickenpox virus (varicella-zoster virus). ZOSTAVAX works by helping your immune system protect you from getting shingles. If you do get shingles even though you have been vaccinated, ZOSTAVAX may help prevent the nerve pain that can follow shingles in some people.
ZOSTAVAX may not protect everyone who gets the vaccine. ZOSTAVAX cannot be used to treat shingles once you have it.
What do I need to know about shingles and the virus that causes it?
Shingles is caused by the same virus that causes chickenpox. Once you have had chickenpox, the virus can stay in your nervous system for many years. For reasons that are not fully understood, the virus may become active again and give you shingles. Age and problems with the immune system may increase your chances of getting shingles.
Shingles is a rash that is usually on one side of the body. The rash begins as a cluster of small red spots that often blister. The rash can be painful. Shingles rashes usually last up to 30 days and, for most people, the pain associated with the rash lessens as it heals.
Who should not get ZOSTAVAX?
You should not get ZOSTAVAX if you:
- are allergic to any of its ingredients.
- are allergic to gelatin or neomycin.
- have a weakened immune system (for example, an immune deficiency, leukemia, lymphoma, or HIV/AIDS).
take high doses of steroids by injection or by mouth.
are pregnant or plan to get pregnant.
- You should not get ZOSTAVAX to prevent chickenpox.
- Children should not get ZOSTAVAX.
- have a weakened immune system (for example, an immune deficiency, leukemia, lymphoma, or HIV/AIDS).
How is ZOSTAVAX given?
ZOSTAVAX is given as a single dose by injection under the skin.
What should I tell my health care provider before I get ZOSTAVAX?
You should tell your health care provider if you:
- have or have had any medical problems.
- take any medicines, including non-prescription medicines, and dietary supplements.
- have any allergies, including allergies to neomycin or gelatin.
- had an allergic reaction to another vaccine.
- are pregnant or plan to become pregnant.
- are breast-feeding.
Tell your health care provider if you expect to be in close contact (including household contact) with newborn infants, someone who may be pregnant and has not had chickenpox or been vaccinated against chickenpox, or someone who has problems with their immune system. Your health care provider can tell you what situations you may need to avoid.
What are the possible side effects of ZOSTAVAX?
The most common side effects that people in the clinical studies reported after receiving the vaccine
include:
- redness, pain, itching, swelling, warmth, or bruising where the shot was given.
- headache.
Tell your healthcare provider if you have any new or unusual symptoms after you receive ZOSTAVAX.
What are the ingredients of ZOSTAVAX?
Active Ingredient: a weakened form of the varicella-zoster virus.
Inactive Ingredients: sucrose, hydrolyzed porcine gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride.
What else should I know about ZOSTAVAX?
Vaccinees and their health care providers are encouraged to call (800) 986-8999 to report any exposure to ZOSTAVAX during pregnancy.






Nice blog post on Zostavax (Zoster Vaccine Live), Is It For You?! Thoroughly love this posts!
As I am on Medicare they will not pay for a Shingles vaccination, please let me know the cost?
Thank you
Ed Houser
Medicare D pays for it – if bought in the pharmacy about $200